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. 2013 Nov 19;17(12):1525–1536. doi: 10.1111/jcmm.12177

Figure 1.

Figure 1

(A–F) Control ileal specimens. (A and E) Double immunofluorescence labelling for CD34 (green) and CD31 (red). In A, nuclei are counterstained with DAPI. (B–D and F) CD34 immunoperoxidase labelling with haematoxylin counterstain. (A) Mucosa. Note a telocyte (TC) near a glandular crypt (arrow). (B) TC are numerous in the muscularis mucosae and submucosa. (C) Muscularis mucosae. TC are mostly oriented parallel to each other and show a slender-nucleated body and two long processes (arrows). Inset: CD34 immunofluorescence labelling with DAPI counterstain. At higher magnification view, TC varicose processes (telopodes) are identifiable. (D) Submucosa. TC have a roundish body with two or three processes. Note a ganglia of the submucosal plexus surrounded by TC (arrows). (E) Submucosa. TC are particularly concentrated around large blood vessels, where they closely encircle the adventitial layer (arrows), and some TC are located among vascular smooth muscle cells within the vessel wall. Endothelial cells are CD34/CD31 double-positive, while TC are CD34-positive and CD31-negative. (F) Submucosa. TC are located around lymphatic vessels (arrow). Inset: Note the TC processes surrounding the discontinous basal lamina of a lymphatic vessel. mm: muscularis mucosae; SM: submucosa; BV: blood vessel; LV: lymphatic vessel. Scale bars are indicated in each panel.