Table 2.
Comparison of GGT and other commonly recognised 4R-tauopathies
| Pathological and biochemical features | Has this feature been documented in this particular disorder? |
||||
|---|---|---|---|---|---|
| GGT | PSP | CBD | AGD | FTLD-MAPT | |
| Neuronal tau inclusionsa | Y | Y | Y | Y | Y |
| Oligodendroglial tau inclusionsa | Y | Y | Y | Y | Y |
| Coiled body inclusions b | N | Y | Y | Y | Y |
| Globular oligodendroglial inclusions b | Y | N | N | N | Yd |
| Gallyas-positive oligodendroglial inclusions | Y | Y | Y | Y | Y |
| Astrocytic tau inclusionsa | Y | Y | Y | Y | Y |
| Tufted astrocytes | Yc | Y | N | N | Y |
| Astrocytic plaques | N | N | Y | N | Y |
| Gallyas-positive astrocytic inclusions b | N | Y | Y | Y | Y |
| 4R tau isoforms depositedb | Y | Y | Y | Y | Y |
| 68 and 64 kDa tau bands | Y | Y | Y | Y | Y |
| 35 kDa tau band b | Y | Y | N | -e | Y |
GGT globular glial tauopathies, PSP progressive supranuclear palsy, CBD corticobasal degeneration, AGD argyrophilic grains disease, FTLD-MAPT frontotemporal lobar degeneration with MAPT mutation, 4R 4-repeat
a
Tau inclusions identified by phospho-tau immunohistochemistry
b
Predominant
c
Astrocytic inclusions may be indistinguishable from tufted astrocytes based on morphology alone
d
Oligodendroglial inclusions with a globular morphology, described as “stout coiled bodies”, have been reported in FTLD-MAPT [11]
e
Unknown