Skip to main content
. Author manuscript; available in PMC: 2014 Feb 5.
Published in final edited form as: Acta Neuropathol. 2013 Aug 31;126(4):537–544. doi: 10.1007/s00401-013-1171-0

Table 2.

Comparison of GGT and other commonly recognised 4R-tauopathies

Pathological and biochemical features Has this feature been documented in this particular disorder?
GGT PSP CBD AGD FTLD-MAPT
Neuronal tau inclusionsa Y Y Y Y Y
Oligodendroglial tau inclusionsa Y Y Y Y Y
Coiled body inclusions b N Y Y Y Y
Globular oligodendroglial inclusions b Y N N N Yd
Gallyas-positive oligodendroglial inclusions Y Y Y Y Y
Astrocytic tau inclusionsa Y Y Y Y Y
Tufted astrocytes Yc Y N N Y
Astrocytic plaques N N Y N Y
Gallyas-positive astrocytic inclusions b N Y Y Y Y
4R tau isoforms depositedb Y Y Y Y Y
68 and 64 kDa tau bands Y Y Y Y Y
35 kDa tau band b Y Y N -e Y

GGT globular glial tauopathies, PSP progressive supranuclear palsy, CBD corticobasal degeneration, AGD argyrophilic grains disease, FTLD-MAPT frontotemporal lobar degeneration with MAPT mutation, 4R 4-repeat

a

Tau inclusions identified by phospho-tau immunohistochemistry

b

Predominant

c

Astrocytic inclusions may be indistinguishable from tufted astrocytes based on morphology alone

d

Oligodendroglial inclusions with a globular morphology, described as “stout coiled bodies”, have been reported in FTLD-MAPT [11]

e

Unknown

HHS Vulnerability Disclosure