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. Author manuscript; available in PMC: 2014 Feb 5.
Published in final edited form as: Psychopharmacology (Berl). 2012 May 31;224(2):277–287. doi: 10.1007/s00213-012-2751-8

Fig. 6.

Fig. 6

In situ hybridisation autoradiograms showing M4 mRNA levels in treatment-naive floxed WT (a) and D1-M4-KO (b) mice at the level of the dorsal striatum. Magnification bar = 1 mm. (c) Quantification revealed a prominent reduction in the nucleus accumbens (NAcc) and the caudate-putamen (CPU) in D1-M4-KO mice compared to WT mice while there were no significant differences in the frontal cortex (FC), hippocampal dentate gyrus (DG) and subfields CA3/CA1. Data represent group mean ± SEM. **p<0.01, ***p<0.001 vs. WT (Student’s t-test; n=6)