Table 1.
Inferred Components of DNA Replication in the LACA and in the Ancestor of Each Major Phylum
| LACA | Thaumarchaeota/Aigarchaeota | Korarchaeaota | Crenarchaeota | Euryarchaeota |
|---|---|---|---|---|
| Cdc6/Orc1-1 | Cdc6/Orc1-1 | Cdc6/Orc1-1 | Cdc6/Orc1-1 | |
| Cdc6/Orc1-2 | Cdc6/Orc1-2 | Cdc6/Orc1-2 | Cdc6/Orc1-2 | Cdc6/Orc1-2 |
| MCM | MCM | MCM | MCM | MCM |
| GINS51 | GINS51 | GINS51 | GINS51 | GINS51 |
| GINS23 | GINS23 | GINS23 | GINS23 | GINS23 |
| RPA1 | RPA1 | RPA1 | RPA1 | |
| SSB | SSB | SSB | SSB | |
| PolB | PolB | PolB (X2) | PolB (X2) | PolB |
| PolD-L/S | PolD-L/S | PolD-L/S | DP-L/S | |
| RFC-S/L | RFC-S/L | RFC-S/L | RFC-S/L | RFC-S/L |
| PCNA | PCNA | PCNA | PCNA (X2) | PCNA |
| Pri-S/L | Pri-S/L | Pri-S/L | Pri-S/L | Pri-S/L |
| RNaseH II | RNaseH II | RNaseH II | RNaseH II | RNaseH II |
| FEN-1 | FEN-1 | FEN-1 | FEN-1 | FEN-1 |
| ATP DNA ligase | ATP DNA ligase | ATP DNA ligase | ATP DNA ligase | ATP DNA ligase |
| TopoIV-A/B | TopoVI-A/B | TopoVI-A/B | TopoVI-A/B | TopoVI-A/B |
| TopoIB | TopoIB | |||
| Root-dependent components | ||||
| Thaumarchaeota/“Aigarchaeota” → PolD-L/S, RPA, SSB, TopoIB | ||||
| Korarchaeota → PolD-L/S, RPA, SSB | ||||
| Crenarchaeota → SSB | ||||
| Euryarchaeota → PolD-L/S, RPA | ||||
Note.—Additional components that would have been present in the LACA according to a rooting in each of the four major phyla are indicated. Components shown in bold have homologs in eukaryotes and those shown in gray are root dependent.