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. 2014 Jan 6;6(1):149–160. doi: 10.1093/gbe/evu007

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© The Author(s) 2014. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 1.— — Schematic representation of menaquinone biosynthetic pathways. MenF: isochorismate synthase, including Chorismate_bind (Pfam: PF00425) protein domain; MenD: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, including TPP_enzyme_C (PF02775), TPP_enzyme_M (PF00205), and TPP_enzyme_N (PF02776) domains; MenH: (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate synthase, including Abhydrolase_1 (PF00561) domain; MenC: o-succinylbenzoate synthase, including MR_MLE (PF01188) and MR_MLE_N (PF02746) domains; MenE: o-succinylbenzoate-CoA ligase, including AMP-binding (PF00501) domain; MenB: 1,4-dihydroxy-2-naphthoyl-CoA synthase, including ECH (PF00378) domain; MenI: 1,4-dihydroxy-2-naphthoyl-CoA thioesterase, including 4HBT (PF03061) domain; MqnA: futalosine synthase, including VitK2_biosynth (PF02621) domain; MqnB: futalosine hydrolase, including PNP_UDP_1 (PF01048) domain; MqnC: dehypoxanthinyl futalosine cyclase, including Radical_SAM (PF04055) and Radical_SAM_N (PF08497) domains; MqnD: 1,4-dihydroxy-6-naphthoate synthase, including VitK2_biosynth (PF02621) domain. *Adenosine could be a precursor to synthesize aminodeoxyfutalosine via MqnA (Arakawa et al. 2011). The nonpolar moiety of menaquinone is displayed in blue, and the polar moiety is displayed in red.