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Plasma concentration-time profile, in a representative patient of enterohepatic recirculation, for irinotecan (filled circle), SN-38 (open circle), and APC (inverted triangle). Irinotecan double dagger secondary peak after the end of the infusion indicative of enterohepatic recirculation. Symbols represent measured plasma concentration, and solid lines are obtained from predicted concentrations using the recirculation model connected point by point
