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. 2014 Feb 5;9(2):e81817. doi: 10.1371/journal.pone.0081817

Figure 2. Diagram of the prototrophic vaccine candidate, VCUSM21P, construction.

Figure 2

The diagram is a schematic representation of ΔhemA mutation removed from VCUSM21 chromosome, and replacing it with the native hemA gene from V. cholerae O139. It shows the double copies of Δctx operon, ΔrtxC/A, and hemA/M genes in VCUSM21P. Gene designations: as Figure 1.