Skip to main content
. 2014 Feb 5;9(2):e87113. doi: 10.1371/journal.pone.0087113

Table 4. IPA pathway analysis of genes containing SNV, gene fusions or amplifications.

ID Pathways Score Number of focus molecules Genes from dataset in network
1 Cell Cycle, Cellular Assembly and Organization, DNA Replication, Recombination, and Repair 49 27 AGAP2, AGPS, AIM2, ANAPC10, CCT2, CDK4, CUL1, DYRK2, E2F7, EGLN1, GRIP1, HELB, HMGA2, IFI16, KIF5A, MARS, MDM2, OS9, PNKD, PRRC2C, PYHIN1, RFTN1, SDHC, UHMK1, USP21, USP44, USP9Y
2 Cell-To-Cell Signaling and Interaction, Molecular Transport, Small Molecule Biochemistry 41 23 AKR1C3, ARHGAP9, CRP, DUSP6, F11R, FCER1A, FCER1G, FCGR2A, FCGR2B, FCGR3B, FCRLA, FCRLB, KLF13, NTN4, PAWR, PPFIA2, PTPRB, PTPRD, PTPRH, PTPRR, RGS4, RGS5, STK24
3 Cell-To-Cell Signaling and Interaction, Nervous System Development and Function, Post-Translational Modification 38 22 AP2A2, caspase, CLP1, CPSF6, CYP27B1, FRS2, GAS2, MLL2, NCOR2, NLGN1, NR1I3, NR2C1, NRXN1, NUMA1, PFDN2, SYT1, TAB2, TBL1Y, UBAC1, VAMP4, ZDHHC17, ZFPM1
4 Cell Morphology, Cellular Assembly and Organization, Connective Tissue Disorders 27 17 APOA2, AVIL, CSRP2, DDIT3, DEDD, ESPN, GDA, HLA-DMA, LAMA5, LYZ, MYOC, NELL1, OSBPL8, RGMA, RRBP1, SACS, SGSM2,
5 Connective Tissue Disorders, Developmental Disorder, Skeletal and Muscular Disorders 25 16 ADAMTS4, AKAP6, BAIAP2, DCTN2, DDR2, DISC1, GLI3, HERC2, KCNC2, KDM5D, MPZ, MRC2, NIT1, RAB3IP, SHC2, ZIC3
6 Cellular Compromise, Cellular Function and Maintenance, Small Molecule Biochemistry 23 15 CADM3, CAMSAP1, DDX3Y, DERL3, FGD6, KCNG1, METTL1, NACC2, NAV3, PPOX, RSF1, SCAPER, TOX2, TSFM, UFC1
7 Lipid Metabolism, Molecular Transport, Ophthalmic Disease 21 14 ATP11A, BBS10, CHD2, DNM3, EHD2, FANCF, LCN1, NUF2, PIP4K2C, PTK7, SASH1, STXBP5, TBC1D15, TOMM40L
8 Cell-To-Cell Signaling and Interaction, Infectious Disease, Inflammatory Response 21 14 C11orf67, CCDC41, CCDC94, CPM, GALNTL4, INTS4, KCNT1, OR10J1, PRKRIR, SBNO2, SEPT9, USF1, XRCC6BP1, ZDHHC14