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. 2014 Feb 5;9(2):e87421. doi: 10.1371/journal.pone.0087421

Figure 2. Trpv2 is responsible for AVP neuron overactivation in aged rats.

Figure 2

A- Double immunohistochemistry of AVP neurons and Trpv2, demonstrating the expression of Trpv2 in AVP-IR neurons. B- Immunohistochemistry of Trpv2 in adult rats under control conditions or after LPS treatment, and in aged rats. C- Trpv2 mRNA levels in the SON (RT-PCR, expressed in arbitrary units, AU,) in adult and aged rats. D- Intensity of Trpv2 immunostaining (in AU) in adult rats, injected i.p. with buffer or LPS. E- Intensity of Trpv2 immunostaining (in AU) in adult rats, and in aged rats into which buffer or IL-6Ab was injected centrally. F- and G- Plasma AVP and apelin concentrations in aged rats centrally injected with buffer or IL-6Ab. H- and I-Plasma AVP and apelin concentrations in aged rats centrally injected with buffer or ruthenium red (+ RR). Plasma AVP and apelin levels in control and treated aged rats are expressed as a percentage of the mean level in control aged rats.* p<0.05; ** p<0.01; *** p<0.001.