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. 2014 Feb 5;9(2):e87774. doi: 10.1371/journal.pone.0087774

Figure 4. Downregulated gene expression of P53, P16, P21 and Caspase-3 in CD4+CD25hi Tregs of aged UBC patients.

Figure 4

Tregs were sorted by FACS, mRNA levels were detected by real-time quantitative PCR. In Aged UBC Patiens, apoptosis regulatory genes Caspase-3, P53, P16 and P21 mRNA expression (2−△△CT = 1183.42±321.17, 15.66±4.83, 23.06±4.59 and 2415.85±863.72, respectively) decreased in Tregs of Aged UBC patients (p<0.05 for each Mann-Whitney U Test). Data were expressed as the mean ± SD. ▴ vs. Teffs sorted from Aged UBC patients, P<0.05.