Table 2. Analysis of association between MMP-1 SNPs and the risk of occurrence of gastric cancer.
| Genotype | GC Patient | Controls | OR | 95% CI | P value | ||
| n | % | N | % | ||||
| MMP-1.1 (−1607 1G/2G) | 145 | 145 | |||||
| 1G1G | 23 | 15.9 | 20 | 13.8 | 1 (Ref) | ||
| 1G2G | 66 | 45.5 | 72 | 49.7 | 0.742 | 0.353–1.559 | 0.430 |
| 2G2G | 56 | 38.6 | 53 | 36.6 | 0.746 | 0.340–1.637 | 0.465 |
| 1G2G+2G2G | 122 | 84.1 | 125 | 86.3 | 0.742 | 0.364–1.511 | 0.411 |
| 1G allele | 112 | 38.6 | 112 | 38.6 | 1 (Ref) | ||
| 2G allele | 178 | 61.4 | 178 | 61.4 | 1.000 | 0.716–1.397 | 1.000 |
| MMP-1.2 (−519 A/G) | 145 | 145 | |||||
| AA | 91 | 62.8 | 100 | 69.0 | 1 (Ref) | ||
| AG | 49 | 33.8 | 41 | 28.3 | 1.154 | 0.672–1.982 | 0.603 |
| GG | 5 | 3.4 | 4 | 2.8 | 1.640 | 0.382–7.047 | 0.506 |
| AG+GG | 54 | 37.2 | 45 | 31.0 | 1.194 | 0.705–2.020 | 0.510 |
| A allele | 231 | 79.7 | 241 | 83.1 | 1 (Ref) | ||
| G allele | 59 | 20.3 | 49 | 16.9 | 1.256 | 0.826–1.911 | 0.337 |
| MMP-1.3 (−422 T/A) | 145 | 145 | |||||
| TT | 17 | 11.7 | 17 | 11.7 | 1.221 | 0.547–2.725 | 0.626 |
| TA | 53 | 36.6 | 51 | 35.2 | 1.000 | 0.581–1.722 | 0.999 |
| AA | 75 | 51.7 | 77 | 53.1 | 1 (Ref) | ||
| TA+TT | 70 | 48.3 | 68 | 46.9 | 1.065 | 0.646–1.755 | 0.806 |
| T allele | 87 | 30 | 85 | 29.3 | 1.034 | 0.724–1.476 | 0.927 |
| A allele | 203 | 70 | 205 | 70.7 | 1 (Ref) | ||
| MMP-1.4 (−340 T/C) | 145 | 145 | |||||
| TT | 69 | 47.6 | 78 | 53.8 | 1 (Ref) | ||
| TC | 64 | 44.1 | 57 | 39.3 | 1.209 | 0.719–2.032 | 0.474 |
| CC | 12 | 8.3 | 10 | 6.9 | 1.499 | 0.556–4.043 | 0.424 |
| TC+CC | 76 | 52.4 | 67 | 46.2 | 1.246 | 0.757–2.051 | 0.388 |
| T allele | 202 | 69.7 | 213 | 73.4 | 1 (Ref) | ||
| C allele | 88 | 30.3 | 77 | 26.6 | 1.205 | 0.839–1.73 | 0.357 |
| MMP-1.5 (−320 T/C) | 145 | 145 | |||||
| TT | 73 | 50.3 | 67 | 46.2 | 1 (Ref) | ||
| TC | 61 | 42.1 | 64 | 44.1 | 0.769 | 0.454–1.303 | 0.329 |
| CC | 11 | 7.6 | 14 | 9.7 | 0.650 | 0.259–1.631 | 0.358 |
| TC+CC | 72 | 49.7 | 74 | 53.8 | 0.734 | 0.443–1.214 | 0.228 |
| T allele | 207 | 71.4 | 198 | 69.3 | 1 (Ref) | ||
| C allele | 83 | 28.6 | 92 | 31.7 | 0.863 | 0.605–1.231 | 0.469 |
Adjusted OR calculated for age, sex and addiction, by binary logistic regression model using SPSS v16.0 software. P value is for χ2 test showing the significance of difference in the distributions of the genotypes and alleles between patients and controls. OR = Odds ratio, CI = Confidence Interval, Ref = Reference genotype or allele to calculate OR.