Figure 4. Rab7 shRNA expressing tumors demonstrate increased cell invasion into surrounding murine tissue.

H&E stained s.c. tumor cross sections with the surrounding murine tissue and skin shown adjacent to the tumor. Rab7 knockdown tumors display increased infiltration into the tissue layer underlying the skin compared to control tumors. In addition, the tissue displays increased disorder and loss of integrity surrounding the Rab7 knockdown tumors. Scale bar: 100 µm.