Table 4. The methylation status (methylation %) of the promoter region covered by the second EPHX1 primer set in the peripheral blood samples from healthy women and PCOS patients in the second cohort (Control = 49, PCOS = 67).
CpG sites | Control | PCOS | Delta value | p-value |
EPHX1 _CpG_8 | 6.9±0.3 | 6.7±0.4 | 0.2 | 0.72 |
EPHX1 _CpG_9 | 5.2±0.8 | 5.5±0.7 | 0.3 | 0.89 |
EPHX1 _CpG_10.11.12 | 17.6±0.5 | 16.8±0.6 | 0.8 | 0.31 |
EPHX1 _CpG_13.14 | 10.7±0.5 | 8.5±0.5 | 2.2 | <0.05 |
EPHX1 _CpG_15.16 | 6.9±0.7 | 6.5±0.5 | 0.4 | 0.71 |
EPHX1 _CpG_17 | 2.4±0.4 | 2.1±0.3 | 0.3 | 0.44 |
EPHX1 _CpG_19-24 | 24.3±0.9 | 21.4±0.8 | 2.9 | <0.05 |
EPHX1 _CpG_26 | 2.4±0.4 | 2.1±0.3 | 0.3 | 0.44 |
EPHX1 _CpG_33 | 12.9±0.7 | 11.6±0.5 | 1.3 | 0.12 |
EPHX1 _CpG_53 | 3.4±0.3 | 3.2±0.3 | 0.2 | 0.64 |
EPHX1 _CpG_54 | 6.6±0.3 | 6.2±0.3 | 0.4 | 0.27 |
EPHX1 _CpG_55.56.57 | 23.7±0.5 | 23±0.3 | 0.7 | 0.22 |
Data represent the mean ± SEM, p values are determined by two-way ANOVA with Bonferroni post-tests.