Figure 4. PGE₂ is responsible for increased TIMP production.

TIMP-1 (A) and TIMP-2 (B) contents in human small and large diameter varicosities (paired SDv and LDv, n = 6) and healthy saphenous veins (SV, n = 4). Treatments with either PGE₂ 10 µmol/L or GW62768X 1 µmol/L are represented by hatched bars. Values were determined by EIA in supernatants after 24 h of incubation. Values are normalized by tissue wet weight; * P<0.05 as determined by one-way-ANOVA followed by the Tukey post-hoc test and by a paired t-test for varicose veins.