Figure 1. Schedule of the projects.
LBPs were administered each day by the intragastric (i.g.) route for 2 weeks, when SCO administration was commenced by a subcutaneous (s.c.) osmotic minipump. Administration of LBP and SCO continued for a further 4 weeks. Behavior tests were performed immediately 1 day after SCO/LBP treatment. Some of animals were sacrificed immediately for biochemical analysis after drug treatment. Twenty-four hours after behavioral testing the rest of animals were sacrificed for immunohistochemical analysis.
