Figure 5. LBP treatment increases neuroblast differentiation in the hippocampal DG.

(A) DCX immunostaining showed the newborn neurons in the subgranular zone of the DG. DCX-immunoreactive neuroblasts (green) were abundant in the DG in the vehicle/saline group. SCO treatment markedly decreased the number of DCX-positive cells. In the LBP/SCO group, the number of DCX-positive cells was restored. Scale bars, 200 µm. (B) Quantification of DCX-positive cells in DG of the three groups in A. (C) The representative images of Calretinin immunostaining. The length of dendrites is markedly injured by SCO compared with control and LBP treatment groups. Scale bars, 100 µm. (D) Quantification of number of Calretinin positive cells in DG in A. Values are means ± SEM (n = 6 animals per groups); **,P<0.01.