Figure 3. Working model of inferred PCP pathway relationships and cell biological functions to be explored through further experimentation. Although Dvl2 can form a complex with Sestd1 and Dact1 as well as with Vangl2, genetic and other evidence suggest that Dact1 and Sestd1 work closely together in Vangl2 trafficking (right side, orange arrows), whereas Dvl2 makes at least partially independent contributions to signal transduction (left side, purple arrows). Both sets of proteins may nevertheless contribute to both processes (dashed arrows), which may indeed be functionally intertwined.