Table 1. Loss of the Dvl2 gene leads to dominant embryonic lethality in a Sestd1 null background.
| Genotype |
Sestd1–/+ Dvl2–/+ |
Sestd1–/+ | Dvl2–/+ |
Sestd1–/+ Dvl2–/– |
Sestd1–/– Dvl2–/+ |
Sestd1–/– | Dvl2–/– | WT |
Sestd1–/– Dvl2–/– |
|---|---|---|---|---|---|---|---|---|---|
|
Neonatal Phenotype |
Normal | Normal | Normal | Normal | embryonic lethality |
Short tail No genital tubercle |
Normal | Normal | embryonic lethality |
|
Neonates Observed |
13 | 6 | 7 | 4 | 0 | 4 | 2 | 2 | 0 |
|
Neonates Expected |
9.5 | 4.75 | 4.75 | 4.75 | 4.75 | 2.375 | 2.375 | 2.375 | 2.375 |
|
Predicted Mendelian Ratio |
1/4 | 1/8 | 1/8 | 1/8 | 1/8 | 1/16 | 1/16 | 1/16 | 1/16 |
Sestd1–/+; Dvl2–/+ X Sestd1–/+; Dvl2–/+ (total = 38)