Figure 3. Evaluation of a protective effect of 2-drug combinations (in the concentration range from 0.5 to 5.0 µM) against H2O2-induced myocardial apoptosis in ventricular cardiomyocytes of neonatal rats.
A–G. Combination effects of curcumin with one of the other drugs at a dose ratio of 1∶1; H. The combination effect of celecoxib and silibinin at a dose ratio of 1∶1. The red line with triangles shows the results of calculation of the combination index. A combination index of less than 1.0 indicates potential synergism of the 2 drugs in question.