Table 3. CHRN variants and propensity to smoke or chew tobacco.
Adjustment model | n | Fold-change in tobacco use/day (95% CI) | P- Value |
Smoking propensity ? (Cigarettes/day) | |||
rs16969968 (CHRNA5) | |||
Base model$ | 388 | 1.13 (0.96– 1.34) | 0.15 |
Base+ chewing frequency | 388 | 1.13 (0.95– 1.34) | 0.16 |
Base, among never chewers only | 212 | 1.19 (0.98– 1.44) | 0.08 |
rs578776 (CHRNA3) | |||
Base model$ | 383 | 0.99 (0.86– 1.13) | 0.87 |
Base+ chewing frequency | 383 | 0.99 (0.86– 1.13) | 0.87 |
Base, among never chewers only | 205 | 0.95 (0.82– 1.11) | 0.54 |
Propensity to chew tobacco* (Chewing events/day) | |||
rs16969968 (CHRNA5) | |||
Base model$ | 622 | 1.13 (1.01– 1.25) | 0.03 |
Base+ smoking frequency | 622 | 1.13 (1.01– 1.26) | 0.03 |
Base, among never smokers only | 446 | 1.19 (1.06– 1.34) | 0.003 |
rs578776 (CHRNA3) | |||
Base model$ | 613 | 0.91 (0.84– 0.99) | 0.04 |
Base+ smoking frequency | 613 | 0.91 (0.84– 0.99) | 0.04 |
Base, among never smokers only | 435 | 0.88 (0.81– 0.97) | 0.01 |
derived from linear regression of log transformed number of cigarettes smoked per day as outcome, respective CHRN variant as explanatory.
derived from linear regression of log transformed number of chewing events per day as outcome, respective CHRN variant as explanatory.
Base model included age, sex, center and case-control status.
significant p- values are indicated in bold.