Table 4. Association between ADH & ALDH2 variants and risk of oral cancer.
Variant | Controls | Oral cancer cases | |
(variant/reference) | OR (95%CI)* | ||
rs1229984 ( ADH1B) | |||
Per rare allele | 29/744 | 22/596 | 0.97 (0.52– 1.79) |
By alcohol status (p-het = 0.98) | |||
Never drinker | 23/570 | 19/432 | 1.08 (0.55– 2.13) |
Ever drinker | 6/174 | 3/159 | 1.11 (0.22– 5.54) |
By sex (p-het = 0.37) | |||
Men | 20/480 | 11/362 | 0.80 (0.36– 1.76) |
women | 9/264 | 11/234 | 1.49 (0.49– 4.51) |
rs698 ( ADH1C) | |||
Per rare allele | 419/343 | 314/276 | 0.97 (0.82– 1.16) |
By alcohol status (p-het = 0.95) | |||
Never drinker | 325/264 | 230/181 | 0.98 (0.80– 1.20) |
Ever drinker | 94/79 | 81/66 | 0.96 (0.66– 1.41) |
By sex (p-het = 0.46) | |||
Men | 265/217 | 188/149 | 0.99 (0.80– 1.23) |
women | 154/126 | 126/100 | 0.86 (0.62– 1.19) |
rs1573496 ( ADH7) | |||
Per rare allele | 56/721 | 48/581 | 1.18 (0.77– 1.81) |
By alcohol status (p-het = 0.65) | |||
Never drinker | 45/44 | 37/36 | 1.09 (0.67– 1.76) |
Ever drinker | 11/169 | 10/152 | 1.42 (0.51– 3.98) |
By sex (p-het = 0.84) | |||
Men | 37/36 | 28/28 | 1.16 (0.68– 1.96) |
women | 19/256 | 20/232 | 1.27 (0.58– 2.78) |
rs4767364 ( ALDH2) | |||
Per rare allele | 671/101 | 537/82 | 0.92 (0.78– 1.09) |
By alcohol status (p-het = 0.04) | |||
Never drinker | 521/249 | 386/206 | 0.84 (0.69– 1.02) |
Ever drinker | 150/72 | 146/71 | 1.27 (0.89– 1.81) |
By sex (p-het = 0.07) | |||
Men | 421/204 | 326/169 | 1.03 (0.84– 1.26) |
women | 250/117 | 211/108 | 0.72 (0.52– 1.00) |
Odds ratios were derived from log additive model adjusted for age, sex, tobacco exposures and center.
P indicates p-value for heterogeneity.