Table 4. Association between ADH & ALDH2 variants and risk of oral cancer.

Variant	Controls	Oral cancer cases
	(variant/reference)	OR (95%CI)*
rs1229984 ( ADH1B)
Per rare allele	29/744	22/596	0.97 (0.52– 1.79)
By alcohol status (p-het =  0.98)
Never drinker	23/570	19/432	1.08 (0.55– 2.13)
Ever drinker	6/174	3/159	1.11 (0.22– 5.54)
By sex (p-het =  0.37)
Men	20/480	11/362	0.80 (0.36– 1.76)
women	9/264	11/234	1.49 (0.49– 4.51)
rs698 ( ADH1C)
Per rare allele	419/343	314/276	0.97 (0.82– 1.16)
By alcohol status (p-het =  0.95)
Never drinker	325/264	230/181	0.98 (0.80– 1.20)
Ever drinker	94/79	81/66	0.96 (0.66– 1.41)
By sex (p-het =  0.46)
Men	265/217	188/149	0.99 (0.80– 1.23)
women	154/126	126/100	0.86 (0.62– 1.19)
rs1573496 ( ADH7)
Per rare allele	56/721	48/581	1.18 (0.77– 1.81)
By alcohol status (p-het =  0.65)
Never drinker	45/44	37/36	1.09 (0.67– 1.76)
Ever drinker	11/169	10/152	1.42 (0.51– 3.98)
By sex (p-het =  0.84)
Men	37/36	28/28	1.16 (0.68– 1.96)
women	19/256	20/232	1.27 (0.58– 2.78)
rs4767364 ( ALDH2)
Per rare allele	671/101	537/82	0.92 (0.78– 1.09)
By alcohol status (p-het =  0.04)
Never drinker	521/249	386/206	0.84 (0.69– 1.02)
Ever drinker	150/72	146/71	1.27 (0.89– 1.81)
By sex (p-het =  0.07)
Men	421/204	326/169	1.03 (0.84– 1.26)
women	250/117	211/108	0.72 (0.52– 1.00)

^*Odds ratios were derived from log additive model adjusted for age, sex, tobacco exposures and center.

P indicates p-value for heterogeneity.