Table 2. Endogenous metabolites selected as biomarkers in serum profile and their change trends.

Metabolite	RT(min)	CR vs. control
Alanine	5.74	↑*
L-proline	8.4	↑*
Glycine	8.5	↑*
Hisoindol	8.55	↑*
Serine	9.08	↑*
Glutamate	11.95	↑*
L-ornithine	14.16	↑*
D-Glucose	15.14	↓*

↑, the increase in signal;↓, the decrease in signal.

*Key: p<0.05.