Table 4. Measures of albuminuria according to quintile of serum parathyroid hormone.
| Parathyroid Hormone Quintile (pg/ml) | |||||
| <27 | 27-<34 | 34-<42 | 42-<54 | ≥54 | |
| Model 1 | |||||
| uAlb | 1 | 1.09 (0.97, 1.24) p = 0.15 | 1.16 (1.03, 1.31) p = 0.018 | 1.28 (1.12, 1.45) p<0.001 | 1.34 (1.18, 1.52) p<0.001 |
| uCr | 1 | 1.08 (0.99, 1.18) p = 0.07 | 1.13 (1.04, 1.23) p = 0.005 | 1.22 (1.12, 1.33) p<0.001 | 1.19 (1.10, 1.30) p<0.001 |
| ACR | 1 | 1.01 (0.93, 1.10) p = 0.80 | 1.03 (0.94, 1.12) p = 0.55 | 1.05 (0.95, 1.15) p = 0.33 | 1.12 (1.02, 1.23) p = 0.015 |
| FEalb | 1 | 1.02 (0.93, 1.11) p = 0.71 | 1.03 (0.94, 1.12) p = 0.58 | 1.05 (0.96, 1.15) p = 0.33 | 1.14 (1.04, 1.25) p = 0.005 |
| Model 2 | |||||
| uAlb | 1 | 1.10 (0.97, 1.24) p = 0.13 | 1.16 (1.02, 1.31) p = 0.019 | 1.26 (1.11, 1.42) p<0.001 | 1.30 (1.15, 1.47) p<0.001 |
| uCr | 1 | 1.07 (0.99, 1.17) p = 0.091 | 1.10 (1.01, 1.20) p = 0.022 | 1.20 (1.10, 1.30) p<0.001 | 1.16 (1.06, 1.26) p<0.001 |
| ACR | 1 | 1.02 (0.94, 1.11) p = 0.63 | 1.05 (0.96, 1.14) p = 0.32 | 1.05 (0.96, 1.15) p = 0.31 | 1.12 (1.02, 1.23) p = 0.009 |
| FEalb | 1 | 1.02 (0.94, 1.12) p = 0.60 | 1.04 (0.95, 1.13) p = 0.40 | 1.04 (0.95, 1.14) p = 0.36 | 1.13 (1.03, 1.23) p = 0.009 |
| Model 3 | |||||
| uAlb | 1 | 1.14 (1.02, 1.29) p = 0.027 | 1.24 (1.10, 1.40) p<0.001 | 1.34 (1.18, 1.52) p<0.001 | 1.39 (1.22, 1.57) p<0.001 |
| uCr | 1 | 1.08 (0.99, 1.17) p = 0.076 | 1.12 (1.03, 1.22) p = 0.006 | 1.21 (1.11, 1.31) p<0.001 | 1.17 (1.07, 1.27) p<0.001 |
| ACR | 1 | 1.06 (0.97,1.16) p = 0.18 | 1.10 (1.01, 1.20) p = 0.032 | 1.11 (1.01, 1.21) p = 0.031 | 1.19 (1.09, 1.30) p<0.001 |
| FEalb | 1 | 1.05 (0.97, 1.15) p = 0.24 | 1.09 (1.00, 1.18) p = 0.062 | 1.09 (0.99, 1.19) p = 0.069 | 1.17 (1.06, 1.28) p<0.001 |
| Model 4 | |||||
| uAlb | 1 | 1.14 (1.01, 1.28) p = 0.029 | 1.23 (1.09, 1.40) p<0.001 | 1.33 (1.17, 1.51) p<0.001 | 1.37 (1.20, 1.55) p<0.001 |
| uCr | 1 | 1.07 (0.99, 1.16) p = 0.10 | 1.11 (1.02, 1.21) p = 0.011 | 1.19 (1.10, 1.30) p<0.001 | 1.15 (1.05, 1.25) p = 0.002 |
| ACR | 1 | 1.07 (0.98, 1.16) p = 0.14 | 1.11 (1.02, 1.21) p = 0.020 | 1.11 (1.01, 1.22) p = 0.029 | 1.19 (1.08, 1.31) p<0.001 |
| FEalb | 1 | 1.06 (0.97, 1.15) p = 0.20 | 1.09 (1.00, 1.19) p = 0.043 | 1.09 (1.00, 1.20) p = 0.068 | 1.17 (1.07, 1.28) p = 0.001 |
model 1: adjusted for age, gender and race.
model 2: as model 1 but additionally adjusted for BMI, weight, waist circumference, systolic and diastolic blood pressures, total:HDL cholesterol ratio, eGFR, diabetes status, HbA1c.
model 3: as model 2 but additionally adjusted for history of cardiovascular disease, poverty:income ratio, smoking status, CRP, hemoglobin, calcium, time of day of venepuncture,
model 4: as model 3 but additionally adjusted for 25(OH)D quintile, season of measurement, loop diuretic and thiazide diuretic.
uAlb, urine albumin concentration; uCr, urine creatinine concentration; ACR, urine albumin:creatinine ratio; FEalb, fractional excretion of albumin relative to creatinine.