Table 6. Measures of albuminuria according to quintile of total alkaline phosphatase.
| Total ALP quintile (U/L) | |||||
| Model 1 | <51 | 51-<61 | 61-<71 | 71-<83 | ≥83 |
| uAlb | 1 | 1.01 (0.95, 1.08) p = 0.63 | 1.12 (1.06, 1.19) p<0.001 | 1.13 (1.06, 1.21) p<0.001 | 1.31 (1.23, 1.39) p<0.001 |
| uCr | 1 | 1.02 (0.98, 1.06) p = 0.45 | 1.08 (1.03, 1.12) p<0.001 | 1.10 (1.05, 1.14) p<0.001 | 1.10 (1.05, 1.14) p<0.001 |
| ACR | 1 | 1.00 (0.96, 1.04) p = 0.97 | 1.05 (1.00, 1.09) p = 0.046 | 1.03 (0.99, 1.08) p = 0.16 | 1.19 (1.14, 1.25) p<0.001 |
| FEalb | 1 | 0.99 (0.95, 1.04) p = 0.72 | 1.04 (1.00, 1.09) p = 0.068 | 1.02 (0.98, 1.07) p = 0.32 | 1.18 (1.13, 1.24) p<0.001 |
| Model 2 | |||||
| uAlb | 1 | 0.98 (0.91, 1.05) p = 0.53 | 1.05 (0.98, 1.12) p = 0.18 | 1.05 (0.98, 1.13) p = 0.14 | 1.12 (1.05, 1.20) p = 0.001 |
| uCr | 1 | 1.00 (0.96, 1.05) p = 0.88 | 1.05 (1.00, 1.10) p = 0.064 | 1.07 (1.02, 1.12) p = 0.007 | 1.06 (1.01, 1.11) p = 0.015 |
| ACR | 1 | 0.97 (0.93, 1.02) p = 0.30 | 1.00 (0.95, 1.05) p = 0.92 | 0.99 (0.94, 1.04) p = 0.63 | 1.06 (1.01, 1.11) p = 0.024 |
| FEalb | 1 | 0.97 (0.93, 1.02) p = 0.27 | 1.00 (0.95, 1.05) p = 0.97 | 0.98 (0.93, 1.03) p = 0.45 | 1.06 (1.00, 1.11) p = 0.032 |
| Model 3 | |||||
| uAlb | 1 | 0.97 (0.91, 1.03) p = 0.29 | 1.03 (0.97, 1.10) p = 0.29 | 1.01 (0.95, 1.07) p = 0.74 | 1.08 (1.01, 1.15) p = 0.018 |
| uCr | 1 | 1.00 (0.96, 1.04) p = 0.94 | 1.04 (1.00, 1.09) p = 0.039 | 1.06 (1.02, 1.10) p = 0.007 | 1.04 (1.00, 1.09) p = 0.037 |
| ACR | 1 | 0.97 (0.93, 1.01) p = 0.17 | 0.99 (0.95, 1.03) p = 0.67 | 0.96 (0.91, 1.00) p = 0.046 | 1.03 (0.99, 1.09) p = 0.18 |
| FEalb | 1 | 0.97 (0.93, 1.01) p = 0.16 | 0.99 (0.95, 1.03) p = 0.66 | 0.96 (0.91, 1.00) p = 0.030 | 1.03 (0.98, 1.08) p = 0.19 |
model 1: adjusted for age, gender and race.
model 2: as model 1 but additionally adjusted for BMI, weight, waist circumference, systolic and diastolic blood pressures, total:HDL cholesterol ratio, eGFR, diabetes status, HbA1c.
model 3: as model 2 but additionally adjusted for history of cardiovascular disease, poverty:income ratio, smoking, CRP, alanine transaminase, aspartate transaminase, hemoglobin, calcium, phosphorus.
uAlb, urine albumin concentration; uCr, urine creatinine concentration; ACR, urine albumin:creatinine ratio; FEalb, fractional excretion of albumin relative to creatinine.