Table 2.
Cytopenias and their Grading (CTCAEv3.0) in patients with rheumatic disorders.
| CTD (n)/disease (n) | Anemia −/+ (n), [%] | Grade/ anemia (n), [%] | Neutropenia −/+ (n), [%] | Grade/ neutropenia | Lym/penia −/+ (n), [%] | Grade/lymphopenia | Thromb/penia −/+ (n), [%] | Grade/thrombocytopenia |
|---|---|---|---|---|---|---|---|---|
| RA (38) | (21/17) | 0: (21) [55.3] | (34/4) | 0: (34) [89.5] | (35/3) | 0: (35) [92.1] | (31/6) | 0: (31) [83.8] |
| [55.3/44.7] | 1: (8) [21.0] | [89.5/10.5] | 1: (3) [7.9] | [92.1/7.9] | 1: (2) [5.3] | [83.8/16.2] | 1: (4) [10.8] | |
| 2: (9) [23.7] | 2: (1) [2.6] | 2: (1) [2.6] | 2: (1) [2.7] | |||||
| 3: (1) [2.7] | ||||||||
|
| ||||||||
| SLE (25) | (13/12) | 0: (13) [52.0] | (19/4) | 0: (19) [82.6] | (19/5) | 0: (19) [79.2] | (21/4) | 0: (21) [84.0] |
| [52.0/48.0] | 1: (7) [28.0] | [82.6/17.4] | 1: (3) [13.0] | [79.2/20.8] | 1: (2) [8.3] | [84.0/16.0] | 1: (4) [16.0] | |
| 2: (2) [8.0] | 2: (1) [4.4] | 2: (1) [4.2] | ||||||
| 3: (2) [8.0] | 3: (2) [8.3] | |||||||
| 4: (1) [4.0] | ||||||||
|
| ||||||||
| SS (17) | (14/3) | 0: (14) [82.3] | (15/2) | 0: (15) [88.2] | (17/0) | 0: (17) [100.0] | (16/1) | 0: (16) [94.1] |
| [82.4/17.6] | 1: (1) [5.9] | [88.2/11.8] | 1: (2) [11.8] | [100.0/0.0] | [94.1/5.9] | 1: (1) [5.9] | ||
| 2: (2) [11.8] | ||||||||
|
| ||||||||
| Sc (7) | (4/3) | 0: (4) [57.1] | (6/0) | 0: (6) [100.0] | (5/1) | 0: (5) [83.3] | (7/0) | 0: (7) [100.0] |
| [57.1/42.9] | 2: (1) [14.3] | [100.0/0.0] | [83.3/16.7] | 1: (1) [16.7] | [100.0/0.0] | |||
| 3: (2) [28.6] | ||||||||
|
| ||||||||
| Vsc (12) | (9/3) | 0: (9) [75.0] | (12/0) | 0: (12) | (4/8) | 0: (4) [33.3] | (12/0) | 0: (12) [100.0] |
| [75.0/25.0] | 1: (3) [25.0] | [100.0/0.0] | [100.0] | [33.3/66.7] | 1: (2) [16.7] | [100/0.0] | ||
| 2: (3) [25.0] | ||||||||
| 3: (3) [25.0] | ||||||||
|
| ||||||||
| Drm (2) | (1/1) | 0: (1) [50.0] | (2/0) | 0: (2) [100.0] | (1/1) | 0: (1) [50.0] | (2/0) | 0: (2) [100.0] |
| [50.0/50.0] | 3: (1) [50.0] | [100.0/0.0] | [50.0/50.0] | 1: (1) [50.0] | [100.0/0.0] | |||
|
| ||||||||
| ASp (1) | (1/0) | 0: (1) [100.0] | (1/0) | 0: (1) [100.0] | (1/0) | 0: (1) [100.0] | (1/0) | 0: (1) [100.0] |
| [100.0/0.0] | [100.0/0.0] | [100.0/0.0] | [100.0/0.0] | |||||
|
| ||||||||
| MCTD | (7/4) | 0: (7) [63.6] | (7/4) | 0: (7) [63.6] | (8/3) | 0: (8) [72.7] | (9/2) | 0: (9) [81.8] |
| (11) | [63.6/36.4] | 1: (2) [18.2] | [63.6/36.4] | 1: (2) [18.2] | [72.7/27.3] | 1: (1) [9.1] | [81.8/18.2] | 1: (1) [9.1] |
| 2: (2) [18.2] | 2: (1) [9.1] | 2: (0) [0.0] | 4: (1) [9.1] | |||||
| 4: (1) [9.1] | 3: (2) [18.2] | |||||||
|
| ||||||||
| Total | (70/43) | 0: (70) [61.9] | (96/14) | 0: (96) [87.2] | 90/21 | 0: (90) [81.1] | 99/13 | 0: (99) [88.4] |
| (113) | 1: (21) [18.6] | 1: (10) [9.1] | 1: (9) [8.1] | 1: (9) [8.0] | ||||
| [62.0/38.0] | 2: (16) [14.2] | [87.3/12.7] | 2: (3) [2.7] | [81.1/18.9] | 2: (5) [4.5] | [88.4/11.6] | 2: (2) [1.8] | |
| 3: (5) [4.3] | 3: (0) [0.0] | 3: (7) [6.3] | 3: (1) [0.9] | |||||
| 4: (1) [0.9] | 4: (1) [0.9] | 4: (0) [0.0] | 4: (1) [0.9] | |||||
| 5: (0) [0.0] | 5: (0) [0.0] | 5: (0) [0.0] | 5: (0) [0.0] | |||||
RA – rheumatoid arthritis & Still’s disease; SLE – systemic lupus erythematosus with or without antiphospholipid syndrome; SS – Sjögren syndrome; Sc – systemic sclerosis; Vsc – vasculitis; Drm – dermatomyositis; ASp – ankylosing spondylitis; MCTD – mixed connective tissue disease.