Table 5.
Presentation of statistic results between CD55- and/or CD59-red-cell deficiency and hematological parameters or manifestations.
| Influence factor/hematological profile | “PNH-like” red-cell phenotype | CD55 deficiency | CD55%- negativity | CD59 deficiency | CD59%- negativity | CD55-CD59 interaction# | CD55/CD59 red-cell phenotype | |
|---|---|---|---|---|---|---|---|---|
| Anemia | +/− | (NS) | (NS) | (NS) | (NS) | (NS) | (N/T) | (NS) |
|
| ||||||||
| Grade* | (NS) | (NS) | (NS) | (NS) | (NS) | (N/T) | (NS) | |
|
| ||||||||
| Hemoglobin | F=2.874 | F=6.092 | F=3.040 | (NS) | (NS) | (NS) | F=2.404 (p=0.071) | |
| (p=0.093) | δ=−1.4534 | (p=0.052) | (−/+) – (+/+) | |||||
| δ (0–10%): −1.439 | (−/+) – (+/−) | |||||||
| rs=−0.205 | (−/−) – (+/−) | |||||||
|
| ||||||||
| +/− | (StS) | (StS) | (StS) | (StS) | (StS) | (N/T) | (StS) | |
| OR=0.078 | OR=0.209 | 0–10% | CD55(+) | [Only CD55(+)] | OR=1/12.778 | |||
| OR=0.2051 | (p=0.044) | 0–10% | ||||||
| Neutro-penia | (p=0.044) | |||||||
|
| ||||||||
| Grade* | (NS) | (NS) | (NS) | (NS) | (NS) | (N/T) | (NS) | |
|
| ||||||||
| Neutrophils | F=16.077 | F=4.06 | F=2.406 | (NS) | (NS) | F=5.035 | F=5.67 | |
| δ=+2.582 | (p=0.095) | (−/+) – (+/+) | ||||||
| (+/−) – (+/+) | ||||||||
| (−/−) – (+/+) | ||||||||
|
| ||||||||
| Lympho-penia | +/− | (NS) | (NS) | (NS) | (NS) | (NS) | (N/T) | (NS) |
|
| ||||||||
| Grade* | (NS) | (NS) | (StS) ? | (NS) | (NS) | (N/T) | (NS) | |
| (p=0.0203) | ||||||||
|
| ||||||||
| (NS) | F=2.937 | F=0.156 | F=4.623 | F=2.388(p=0.097) | (NS) | F=2.713 | ||
| Lymphocytes | (p=0.089) | δ (0–10%)= | δ=+0.363 | δ (0–10%)= | (−/+) – (+/−) | |||
| δ=−0.426 | −0.455 | +0.383 | (−/+) – (−/−) | |||||
| rs=0.118 | rs=−0.157 | |||||||
|
| ||||||||
| Throm/penia | +/− | (NS) | (NS) | (NS) | (NS) | (NS) | (N/T) | (NS) |
|
| ||||||||
| Grade** | (StS) | OR=7.31 | (NS) | (NS) | (NS) | (N/T) | (StS) | |
| OR=17.0 | (p=0.0565) | OR=1/0.059 | ||||||
|
| ||||||||
| F=4.623 | F=3.797 | δ=+48.93 | (NS) | (NS) | (NS) | F=1.759 | ||
| Platelets | δ=+71.59 | (p=0.054) | (p=0.0612) | (−/+) – (+/+) | ||||
| δ=+49.23 | (−/−) – (+/+) | |||||||
| (p=0.0539) | ||||||||
Grade refers to the scale 1–5 of hemocypenias, Grade 0 is not included, apart from thrombocytopenia
in which the written odds ratios refer to the possibility of grade 0 and 1 occurrence.
CD55-CD59 interaction was calculated with Two-way ANOVA, Logarithm transformation was not conducted because there was not such choice offered by the MedCalc.? the existence of true statistically significant result and its aetiology is under question, δ=statistically significant difference that is based on antigen deficiency unless it is mentioned otherwise, (StS)=statistical significant, (NS)=non-significant, (N/T) – not tested, in bold letters whatever statistical parameter-relation is significant (p<0.05).