Figure 2.

(A–C) In vivo magnetic resonance (MR)–near-infrared fluorescent (NIRF) dual-modality imaging of SCC7 tumors.

Notes: Cy5.5-chitosan nanoparticle-Gd(III) nanoparticles were injected into the SCC7-bearing mice, and the mice were visualized by using MR and NIRF imaging. Red circles indicate tumor sites. (A) In vivo MR imaging showed T1-positive contrast effects 1 hour after injection at the tumor sites. (B) In vivo NIRF imaging showed brighter NIRF intensity at the tumor site. In vivo MR imaging 24 hours after injection showed bright contrast effects at the tumor site. (C) In vivo NIRF imaging showed the accumulated Cy5.5-CNP-Gd(III) nanoparticles over time at the tumor sites. Reproduced with permission Nam T, Park S, Lee SY, et al. Tumor targeting chitosan nanoparticles for dual-modality optical/MR cancer imaging. Bioconjug Chem. 2010;21(4):578–582.⁶⁸ Copyright © 2010 American Chemical Society.