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. 2014 Jan 29;9:711–726. doi: 10.2147/IJN.S53717

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© 2014 Key and Leary. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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(A–C) In vivo magnetic resonance (MR)–single-photon emitted tomography (SPECT) images of axial view (top) and coronal view (bottom).

Notes: (A) T2*-weighted MR images before injection of technetium-99m–diethylene triamine pentaacetic acid (^99mTc-DTPA)-ale-Endorem; (B) T2*-weighted MR images 15 minutes after injection of ^99mTc-DTPA-ale-Endorem; (C) SPECT image 45 minutes after injection of ^99mTc-DPA-ale-Endorem; L indicates the liver, S the spleen, showing the accumulation of ^99mTc-DPA-ale-Endorem at those organs with MR imaging and SPECT after injection. Reproduced with permission from Torres Martin de Rosales R, TavaréR, Glaria A, Varma G, Protti A, Blower PJ. (⁹⁹m)Tc-bisphosphonate-iron oxide nanoparticle conjugates for dual-modality biomedical imaging. Bioconjug Chem. 2011;22(3):455–465.⁸² Copyright © 2011 American Chemical Society.