Table 1.
Summarized report of the 36 patient samples and genetic alterations identified in the PI3K/AKT/PTEN pathway.
| Patient No. |
Gender (Age) | Cyst size (cm) |
Location Within Pancreas |
Main duct or Mixed (MD) versus Branch duct (BD) |
IPMN Lesion Analyzed Histologic Subtype Gastric = G Intestinal = I Pancreatobiliary = P and Nuclear Grade (1-3) |
Resection Specimen (Highest Grade of IPMN) |
Resection Specimen (Stage of Invasive Cancer) |
Outcome | PIK3CA mutant |
AKT1 mutant |
PIK3CA amp |
AKT amp |
PTEN LOH |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | F (70) | 3.5 | Head | Main | G (1) | IPMN-2 | - | NED | No | No | No | ||
| 2 | F (79) | 2.2 | Body | Main | P (3) | IPMN-3 | pT1N0 | DOD | No | No | Yes | ||
| 3 | M (64) | 2.0 | Head | Main | I (2) | IPMN-3 | - | Recurrence | No | No | No | ||
| 4 | M (64) | 1.2 | Head | Main | G (1) | IPMN-3 | - | Recurrence | No | No | Yes | ||
| 5 | F (66) | 2.1 | Head | Main | G (1) | IPMN-1 | - | NED | No | No | NA | ||
| 6 | M (78) | 4.5 | Head | Branch | I (2) | IPMN-3 | - | NED | Yes | No | No | ||
| 7 | M (85) | 5.5 | Head | N/A | I (2) | IPMN-3 | pT3N1 | DOD | E17K | No | No | Yes | |
| 8 | F (44) | 1.0 | Head | Main | I (3) | IPMN-3 | - | NED | No | No | Yes | ||
| 9 | F (70) | 3.0 | Head | Main | P (3) | IPMN-3 | - | NED | No | No | No | ||
| 10 | M (75) | 3.0 | Head | Branch | P (3) | IPMN-3 | - | Recur/ DOD | No | No | No | ||
| 11 | F (79) | 2.0 | Head | Main | G (3) | IPMN-3 | - | NED | No | No | No | ||
| 12 | F (75) | 2.0 | Tail | Branch | G (2) | IPMN-2 | - | DOD | No | No | No | ||
| 13 | F (85) | 4.3 | Body | Main | I (3) | IPMN-3 | - | NED | No | No | No | ||
| 14 | F (36) | 4.8 | Head | Main | G (2) | IPMN-2 | - | NED | Yes | No | No | ||
| 15 | F (66) | 2.1 | Head | Main | I (3) | IPMN-3 | pT3N1 | Recur/ DOD | Yes | No | No | ||
| 16 | F (68) | 1.7 | Tail | Main | G (2) | IPMN-2 | - | NED | H1047R | No | No | No | |
| 17 | F (59) | 5.0 | Head | Branch | I (2) | IPMN-3 | NED | No | No | Yes | |||
| 18 | M (70) | 5.2 | Head | Branch | P (3) | IPMN-3 | NED | No | No | No | |||
| 19 | M (73) | 5.5 | Body | Main | G (2) | IPMN-2 | NED | No | No | No | |||
| 20 | M (78) | 1.6 | Head | Main | G (1) | IPMN-3 | pT1N0 | NED | E17K | No | No | No | |
| 21 | F (58) | 1.0 | Body | Main | G (1) | IPMN-1 | - | NED | Yes | No | No | ||
| 22 | M (79) | 5.1 | Tail | Main | P (3) | IPMN-3 | pT3N1 | Recur/DOD | No | Yes | Yes | ||
| 23 | F (58) | 4.0 | Body | Main | I (3) | IPMN-3 | NED | No | No | NA | |||
| 24 | M (71) | 5.0 | Head | Main | I (3) | IPMN-3 | NED | No | No | Yes | |||
| 25 | F (55) | 1.4 | Head/neck | Branch | G (3) | IPMN-3 | NED | No | No | NA | |||
| 26 | F (58) | 1.2 | Body | Branch | G (2) | IPMN-2 | NED | Yes | No | Yes | |||
| 27 | M (53) | 3.6 | Tail | Main | P (3) | IPMN-3 | NED | No | No | No | |||
| 28 | M (61) | 1.5 | Head | Main | I (2) | IPMN-3 | pT1N0 | NED | No | No | No | ||
| 29 | M (74) | 0.5 | Body/tail | Main | P (3) | IPMN-3 | - | Recurrence | No | No | Yes | ||
| 30 | F (78) | 4.5 | Distal | Main | G (2) | IPMN-2 | NED | No | No | NA | |||
| 31 | F (67) | 2.6 | Body | Main | G (2) | IPMN-2 | NED | No | No | NA | |||
| 32 | M (66) | 1.3 | Distal | Branch | I (3) | IPMN-3 | NED | Yes | No | No | |||
| 33 | F (82) | 2.0 | Head | Main | P (3) | IPMN-3 | pT3N1 | DOD | No | No | NA | ||
| 34 | M (68) | 2.0 | Distal | Main | I (3) | IPMN-3 | - | NED | No | No | NA | ||
| 35 | M (72) | 3.0 | Distal | N/A | I (3) | IPMN-3 | NED | E17K | Yes | No | NA | ||
| 36 | F (78) | 1.1 | Head/body | Branch | I (2) | IPMN-2 | NED | No | No | Yes |
IPMN-1 (low grade dysplasia) = IPMN, adenoma; IPMN-2 (moderate dysplasia) = IPMN, borderline tumor; IPMN-3 (high grade dysplasia) = IPMC, carcinoma in situ; NED: No evidence of diseases; DOD: Death of disease; NA: not informative.