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. 2014 Feb 5;9(2):e88297. doi: 10.1371/journal.pone.0088297

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© 2014 Grayson et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(a) Regions comprising the structural rich club are displayed on an average brain surface. Degree k> = 14 was used to define rich club nodes, reflecting the peak value observed in the weighted rich club coefficient curve in (b). Results highlight the involvement of medial parietal/PCC, superior frontal/ACC, insula, and inferior temporal cortex. (b) Rich club coefficients relative to random are shown as weighted in red and as unweighted in dark red. Significant values (p<.05) are signified with an asterisk. (c) Rich club regions from (a) are colored according to community assignments. Below, a spring embedded graph shows rich club nodes and links between them, reflecting a high level of integration between systems. (d, e) Rich club regions with a high Community Index (C > = 3) and a high Distribution Index (D> = 10) are colored. A large proportion of regions are colored, reflecting high levels of integration.