Fig. 1.

Hourly mean change in pulse rate from pre-dose sitting pulse rate (a) and mean change in pulse rate across visits from pre-dose sitting pulse rate (b) for patients who had/did not have pre-existing cardiac conditions or baseline cardiac findings (PCCs), and hourly mean change in pulse rate from pre-dose sitting pulse rate (c) and mean change in pulse rate across visits from pre-dose sitting pulse rate (d) for patients who were receiving/not receiving beta blockers/calcium channel blockers (BBs/CCBs). bpm beats per minute, NBB/NCCB not receiving BBs/CCBs, NPCC no PCCs