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On-study disease activity in patients treated with placebo, by disease activity subgroup. Highly active RRMS was defined as at least two relapses in the year prior to randomization and at least one Gd+ lesion at baseline, all other patients comprised the less active RRMS subgroup. RRMS relapsing-remitting multiple sclerosis, ARR annualized relapse rate, Gd + gadolinium-enhancing
