Fig. 5.

Effects of repetitive systemic administration of 12G5 CXCR4-blocking antibodies on intratibial primary tumor development of 143B-lacZ osteosarcoma cell xenografts. a Representative X-ray images of 143B-lacZ cell-derived tumors in severe combined immunodeficient mice treated with control mouse IgG (top panels) or with 12G5 CXCR4 antibodies (bottom panels). b Primary tumor volumes calculated from caliper measurements of tumor bearing tibiae in control mouse IgG- or 12G5 antibody-treated mice. The results are from two independent experiments with 7 (first experiment) and 6 (second treatment) (open triangle) and 9 (filled circle) mice per indicated group