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. 2013 Nov 28;110(3):602–608. doi: 10.1038/bjc.2013.735

Table 3. Mean (s.d.) observed noncompartmental pharmacokinetic parameters for free ziv-aflibercept.

 
 Ziv-aflibercept
Parameter N Mean s.d.
t1/2
 Day
 7
 4.62
 1.46
CL
 l per day per kg
 7
 0.016
 0.004
Vss
 l kg−1
 7
 0.081
 0.015
Cmax
 mg l−1
 21
 104
 26.2
Clast
 mg l−1
 21
 65.2
 50.8
tmax
 Day
 21
 0.0695
 0.019
tlast
 Day
 21
 7.02
 9.32
AUCinf
 Day × mg l−1
 7
 402
 100
MRTinf Day 7 5.35 1.28

Abbreviations: AUCinf=area under the concentration curve from time zero extrapolated to infinity; CL=clearance; Clast=last positive plasma concentration; Cmax=maximal plasma concentration; MRTinf=mean residence time extrapolated to infinity; tlast=time of the last positive plasma concentration; tmax=time required to reach maximal plasma concentration; t1/2=observed half-life; Vss=volume of distribution at steady state.