Table 2. Predicted nodal information at surgical staging in 1000 endometrioid endometrial cancer patients, for pre-selected and unselected endometrial cancer cases as detailed in the left column.
| |
|
Staging information |
|
||
|---|---|---|---|---|---|
| Patients staged | n | Node-positive cases identified | Node-positive cases missed | NPV | FN |
| Everyone |
1000 |
100 |
0 |
100% |
0% |
| No one |
0 |
0 |
100 |
90% |
10% |
| G3 only |
180 |
34 |
66 |
93% |
7% |
| G2–3 |
450 |
72 |
28 |
97% |
3% |
| G2–3 and G1DMI | 585 | 89 | 11 | 99% | 1% |
Abbreviations: DMI=deep myometrial invasion; FN=false negative; G1,2,3=Grade 1, 2 and 3 endometrioid adenocarcinoma of the endometrium; NPV=negative predictive value.
Assumptions: 10% overall lymph node involvement: 3% for G1, 9% for G2, 19% for G3 (GOG33 data). Grade distribution of 55% G1, 27% G2, 18% G3 tumours. A total of 25% of preoperatively defined G1 tumours have deep myometrial invasion.