Figure 1.

Penalised splines for benzene exposure metrics for AML and sensitivity analyses on disease and exposure history certainty. Log odds ratio of risk of LH cancer subtype as a smooth function of the binary logarithm of cumulative (p.p.m.-years +0.001), average (p.p.m.), and maximum exposure (p.p.m.). In panel D, log odds ratios are plotted against duration on an additive scale. More certain cases refer to those with medium or high case certainty, and subjects with more certain exposure history refer to those with medium or high job history confidence scores. (A) AML: Cumulative benzene exposure (p.p.m.-years). (B) AML: average intensity of benzene exposure (p.p.m.). (C) AML: maximum intensity of benzene exposure (p.p.m.). (D) AML: duration of employment (years).