Table 1. Odds ratios and 95% confidence intervals for acute myeloid leukaemias and chronic lymphoid leukaemias for benzene exposure metrics.
|
Acute myeloid leukaemia |
Chronic lymphoid leukaemia |
|||
|---|---|---|---|---|
| Cases/controls | Odds ratios (95% CI) | Cases/controls | Odds ratios (95% CI) | |
|
Cumulative benzene exposure beyond zero (p.p.m.-years) | ||||
| ⩽0.348 | 20/89 | 1 | 24/117 | 1 |
| >0.348–2.93 | 19/83 | 1.04 (0.50, 2.19) | 32/110 | 1.49 (0.81, 2.76) |
| >2.93 |
21/69 |
1.39 (0.68, 2.85) |
24/118 |
1.05 (0.56, 1.98) |
|
Maximum benzene exposure intensity (p.p.m.) beyond 0.016 p.p.m. | ||||
| ⩽0.016 | 17/87 | 1 | 30/106 | 1 |
| >0.016–0.118 | 13/47 | 1.49 (0.65, 3.37) | 14/86 | 0.55 (0.26, 1.18) |
| >0.118–0.413 | 14/55 | 1.35 (0.59, 3.07) | 21/78 | 0.97 (0.50, 1.87) |
| >0.413 |
16/52 |
1.65 (0.75, 3.63) |
15/75 |
0.72 (0.36, 1.45) |
|
Average benzene exposure intensity (p.p.m.) beyond 0.016 p.p.m. | ||||
| ⩽0.016 | 16/90 | 1 | 31/114 | 1 |
| >0.016–0.081 | 15/46 | 1.97 (0.87, 4.5) | 15/76 | 0.74 (0.36, 1.5) |
| >0.081–0.259 | 13/55 | 1.41 (0.61, 3.3) | 19/86 | 0.83 (0.42, 1.62) |
| >0.259 |
16/50 |
1.90 (0.86, 4.18) |
15/69 |
0.83 (0.41, 1.67) |
|
Duration of employment beyond zero (years) | ||||
| >0–15.6 | 27/115 | 1 | 18/105 | 1 |
| >15.6–28 | 16/77 | 0.96 (0.46, 2.01) | 36/115 | 2.14 (1.08, 4.24) |
| >28 |
17/49 |
1.70 (0.75, 3.87) |
26/125 |
1.22 (0.57, 2.60) |
|
Peak exposure (ever >3 p.p.m. for 1+years) | ||||
| None | 25/124 | 1 | 50/187 | 1 |
| Yes |
35/117 |
1.50 (0.82, 2.75) |
30/138 |
0.69 (0.41, 1.14) |
|
Dermal exposure | ||||
| None | 22/87 | 1 | 29/113 | 1 |
| Low | 0/16 | — | 8/24 | 1.41 (0.56, 3.53) |
| Medium | 11/39 | 1.10 (0.46, 2.61) | 16/74 | 0.82 (0.41, 1.66) |
| High | 27/99 | 1.15 (0.60, 2.22) | 27/134 | 0.76 (0.42, 1.39) |
Abbreviations: CI=confidence interval; p.p.m.=parts per million.