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. 2014 Feb 6;5:20. doi: 10.3389/fgene.2014.00020

Figure 2.

Figure 2

Diagram showing the official gene symbols for the 41 candidate genes associated with ARDS susceptibility and outcomes, depicting both chromosome locations and the number of study samples with statistically significant associations. For each chromosome, lower arrowheads indicate the location of genes with a single sample association, and upper arrowheads indicate the location of genes with statistically significant association findings in at least two study samples. Arrowheads with asterisk indicate more than one gene in that region. Dots denote that the gene was replicated in the only GWAS of ARDS published to date. Underlined gene names indicate that the product has been suggested as a biomarker for ARDS or its progression in at least one study. ACE, angiotensin I converting enzyme; ANGPT2, angiopoietin 2; CXCL2, chemokine (C-X-C motif) ligand 2; DARC, duffy blood group, chemokine receptor; DIO2, deiodinase, iodothyronine, type II; EGF, epidermal growth factor; F5, coagulation factor V (proaccelerin, labile factor); FAS, TNF receptor superfamily, member 6; FTL, ferritin, light polypeptide; GP5, glycoprotein V (platelet); HMOX1, heme oxygenase 1; HMOX2, heme oxygenase 2; IL6, interleukin 6; IL10, interleukin 10; IL18, interleukin 18; IL32, interleukin 32; IRAK3, interleukin-1 receptor-associated kinase 3; LTA, lymphotoxin alpha; MBL2, mannose-binding lectin 2; MIF, macrophage migration inhibitory factor; MYLK, myosin light chain kinase; NAMPT, nicotinamide phosphoribosyltransferase; NFE2L2, nuclear factor (erythroid-derived 2)-like 2; NFKB1, nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; NFKBIA, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor alpha; NQO1, NAD(P)H dehydrogenase, quinone 1; PI3, peptidase inhibitor 3; PLAU, plasminogen activator, urokinase; PPARGC1A, peroxisome proliferator-activated receptor gamma, coactivator 1 alpha; SFTPA1, surfactant protein A1; SERPINE1, serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; SFTPA2, surfactant protein A2; SFTPB, surfactant protein B; SFTPD, surfactant protein D; SOD3, superoxide dismutase 3; STAT1, signal transducer and activator of transcription 1, 91kDa; TIRAP, toll-interleukin 1 receptor (TIR) domain containing adaptor protein; TLR1, toll-like receptor 1; TNF, tumor necrosis factor; TRAF6, TNF receptor-associated factor 6; VEGFA, vascular endothelial growth factor A.