Figure 5.

Whole-brain peripheral benzodiazepine receptor (PBR) concentration is lowered upon administration of glutamate (Glu) scavengers. Peripheral benzodiazepine receptor concentration is a good indicator of neuronal stress. Here we see a significant reduction in PBR concentration as a result of the BGS treatment. Although naïve animals (n=5) have the lowest concentration of PBR, there is a significant difference between saline (n=4) and OxAc+hGOT (human glutamate oxaloacetate transaminase) (n=4) treated groups 7 days after the paraoxon (PO) challenge. One-way analysis of variance with Newman–Keuls multiple comparison test; **P<0.01, ***P<0.001.