Table I.
Clinical characteristics at diagnosis between APLs with and without ED.
| Clinical characteristics | APLs with ED (n=26) | APLs without ED (n=102) | P-value |
|---|---|---|---|
| Gender (male/female) | 16/10 | 58/44 | 0.667 |
| Age (years) | 38.50 (4–83) | 31.12 (13–73) | 0.078 |
| WBC count ×109/l (range) | 19.3 (2.50–95.20) | 5.23 (0.30–32.12) | 0.000 |
| BPC ×109/l (range) | 23 (11.00–58.30) | 27.34 (9.00–59.30) | 0.183 |
| Hemoglobin (g/l) | 82.23±15.11 | 87.67±14.91 | 0.100 |
| Fibrinogen (g/l) | 1.14±0.19 | 1.24±0.18 | 0.009 |
| BMLP (%) | 70.41±10.88 | 74.09±11.83 | 0.152 |
| M3/M3v type | 8/18 | 70/32 | 0.000 |
| CD15+/CD15− | 10/16 | 46/56 | 0.543 |
| HLA-DR+/HLA-DR− | 15/11 | 47/55 | 0.290 |
| CD56+/CD56− | 8/18 | 22/80 | 0.323 |
| CD2+/CD2− | 16/10 | 45/57 | 0.112 |
| BCR1/BCR3 | 8/18 | 74/28 | 0.000 |
| CD34+/CD34− | 17/9 | 34/68 | 0.003 |
Elevated WBC counts (P=0.000), lower fibrinogen concentration (P=0.009), morphologic M3v (P=0.000), CD34+ (P=0.003) and short form (S-, bcr3) of PML/RARα transcript (P=0.000) were significantly associated with ED. APL, acute promyelocytic leukemia; ED, early death; WBC, white blood cell; BPC, blood platelet count; BMLP, bone marrow leukemic promyelocyte; M3v, acutre promyelocytic leukemia variant type.