Table I.
Clinical characteristics and treatment options of 21 patients with desmoid tumors.
| No. | Age (yrs)/gender | Primary site | Size (cm) | SM | Adjuvant treatment | Recurrence | Treatment for recurrence | Last follow-up | PFS | OS |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 12/M | Popliteal fossa | 22×17×11 | + | RT | 2 | Surgery (R1–2), RT (R2) | NED | 91 | 91 |
| 2 | 12/F | Calf | 17×15×5 | + | None | 2 | Surgery (R1) + RT (R2) | NED | 4 | 16 |
| 3 | 14/F | Knee | 4×3×2.4 | + | RT | 3 | Surgery (R1–3), chemotherapy (R3, MTX) | NED | 18 | 53 |
| 4 | 20/F | Forearm | 8×4×3 | + | None | None | None | NED | 67 | 67 |
| 5 | 22/F | Abdomen | 13×8×8.5 | − | None | 4 | Surgery (R1–4), RT (R2) + chemotherapy (TAM, TAL) | Exitus | 1 | 59 |
| 6 | 23/M | Upper arm | 4.2×3.5×3 | − | RT | None | None | NED | 114 | 114 |
| 7 | 25/M | Knee | 1.5×0.2 | − | RT | 1 | Chemotherapy (R1, MTX) | NED | 17 | 24 |
| 8 | 26/F | Buttocks | 7×4×1.5 | − | RT | None | None | NED | 123 | 123 |
| 9 | 27/F | Shoulder | 9×3×2 | − | RT | 2 | Surgery (R1), chemotherapy (see results in text) | AWD | 153 | 170 |
| 10 | 27/F | Abdomen | 7.5×5×2.5 | + | None | None | None | NED | 53 | 53 |
| 11 | 28/F | Abdomen | 4×3.6×1.6 | − | RT | None | None | NED | 8 | 8 |
| 12 | 30/F | Buttocks | 12×8×7.5 | − | RT | None | None | NED | 23 | 23 |
| 13 | 32/M | Abdomen | 2.5×2×2 | + | RT | None | None | NED | 6 | 6 |
| 14 | 35/F | Abdomen | 13×10×5 | − | None | None | None | NED | 3 | 3 |
| 15 | 36/F | Neck | 3×2×1.5 | + | RT | 5 | Surgery (R1–5), RT (R1, R2) + chemotherapy (R3 EPI, R4 IMA, R5 TAM) | NED | 11 | 43 |
| 16 | 36/F | Abdomen | 2.5×1.6×1 | − | None | 1 | Surgery | NED | 62 | 62 |
| 17 | 36/F | Buttocks | 11×10×8 | + | RT | None | None | NED | 108 | 113 |
| 18 | 36/F | Abdomen | 6.2×3.3 | + | None | None | None | NED | 37 | 37 |
| 19 | 38/F | Abdomen | 16×15×11 | − | None | None | None | NED | 2 | 2 |
| 20 | 41/M | Abdomen | 19×13×6.5 | + | RT | None | None | NED | 50 | 50 |
| 21 | 52/F | Shoulder | 40×10×10 | + | RT | 2 | Surgery (R1–2), RT (R2) | NED | 108 | 219 |
F, female; M, male; yrs, years; SM, surgical margin; RT, radiotherapy; PFS, progression-free survival; OS, overall survival; R1–5, recurrence treatment; MTX, methotrexate; EPI, epirubicin; IMA, imatinib; TAM, tamoxifen; TAL, thalidomide; NED, no evidence of disease; AWD, alive with disease.