Table 4. The Effect of Olive Oil on Biomarkers.
| Variable | N | Baseline (SD) | 4 Mo (SD) | Delta (SD) | P-value |
|---|---|---|---|---|---|
| EndoPAT score | 50 | 1.595 (1, 2) | 1.675 (1, 3.16) | 0.09 (−0.72, 1.37) | #0.029 |
| HDL Chol (md/dL) | 49 | 46 (29, 97) | 51 (29, 97) | 0 (−24, 23) | 0.786 |
| LDL Chol (mg/dL) | 49 | 102 (35, 244) | 105 (43, 222) | 1 (−40, 38) | 0.564 |
| Total Chol (mg/dL) | 49 | 178 (94, 312) | 178 (109, 302) | 0 (−63, 45) | 0.789 |
| Triglyceride (mg/dL) | 49 | 106 (25, 311) | 103 (38, 407) | 5 (−229, 219) | 0.346 |
| Oxidized LDL | 49 | 4.29 (2.86) | 4.31 (2.77) | 0.02 (0.85) | 0.79 |
| Hemoglobin | 49 | 13.7 (11.9, 16.6) | 13.6 (11.6, 16.9) | −0.2 (−1.7, 3.1) | 0.119 |
| HsCRP | 51 | 0.101 (0.01, 2.81) | 0.09 (0.01, 1.21) | 0 (−2.68, 0.639) | 0.220 |
| ICAM-1 | 53 | 196 (84, 298) | 183 (91, 239) | −11 (−168, 130) | #<.001 |
| IL-6 | 51 | 1.3 (0.3, 33) | 1.3 (0.5, 5.1) | −0.1 (−30.9, 2.7) | 0.518 |
| WBC | 49 | 6 (3.8, 11.7) | 5.8 (3.7, 10.4) | −0.4 (−5.2, 2.8) | #0.009 |
| Lymphocytes | 48 | 1.845 (0.47, 3.63) | 1.6 (0.64, 3.07) | −0.13 (−0.81, 1.12) | #0.005 |
| Monocytes | 48 | 0.48 (0.27, 0.94) | 0.44 (0.26, 0.97) | −0.03 (−0.51, 0.34) | #0.047 |
| Neutrophils | 48 | 3.69 (1.37, 8.94) | 3.38 (2.11, 6.4) | −0.15 (−5.02, 2.91) | 0.072 |
| Platelet Count | 49 | 242 (124, 367) | 229 (146, 338) | −11 (−128, 51) | #0.047 |
| VCAM-1 | 52 | 575 (368, 1054) | 560 (346, 1166) | −26 (−284, 200) | 0.068 |
| Plasma 8-isoprostanes | 52 | 130.8 (28.71, 310.6) | 164.4 (55.37, 491.6) | 22.39 (−113, 324.7) | 0.003* |
Significant reductions (#) in ICAM-1, Lymphocytes, Monocytes, Platelets, and WBCs are seen after 4 months of OO treatment. There was a trend toward reduction in neutrophils as well. No significant reductions existed with regard to lipid profiles or inflammatory markers. Plasma-8 isoprostane actually increased (*) after OO treatment.