Table 3.

Factors Associated with the Change in Bone Turnover Markers with ART-Initiation

A. Factors Associated with % Change in CTX
	β	SE	P
Pre-ART CD4 cell count <50 cells/mm3	41	18	0.03
Pre-ART CTX (per log difference)	−126	16	<0.01

B. Factors Associated with % Change in OC
	β	SE	P
Age (per year difference)	−1.8	0.8	0.04
TDF (vs. no TDF use)	32	14	0.03
PI (vs. no PI use)	31	14	0.03
Pre-ART sTNFRI (per log difference)	52	16	<0.01
Pre-ART OC (per log difference)	−116	15	<0.01

Models adjusted for age, race, sex, pre-ART CD4 cell count, baseline weight, duration of ART prior to the second sample, TDF-use, PI-use, and pre-ART value of the bone turnover marker

ART, antiretroviral therapy; CTX, C-terminal telopeptide of type I collagen; OC, osteocalcin; TDF, tenofovir; PI, protease; sTNFRI, soluble tumor necrosis factor-α receptor-I