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Scheme of delivery of cyclophosphamide and reovirus (REOLYSIN) in phase I study of immunomodulatory therapy. Cyclophosphamide is delivered 3 days before a 5-day cycle of reovirus with cycles repeated each 4 weeks. The −1 dose level was written into the protocol in case dose-limiting toxicity was encountered in cohort 1, but was not needed during study conduct.
