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. Author manuscript; available in PMC: 2014 Sep 12.
Published in final edited form as: J Med Chem. 2013 Aug 23;56(17):6886–6900. doi: 10.1021/jm400711t

Table 3.

4-CR leading to the formation of the second-generation analogues based on the 7-deazapurine skeleton.

graphic file with name nihms517620u3.jpg
6,7-dideazaadenine Ar1 Ar2 Ar3 % yield
24a graphic file with name nihms517620t25.jpg graphic file with name nihms517620t26.jpg graphic file with name nihms517620t27.jpg 63
24b graphic file with name nihms517620t28.jpg Ph Ph 30
24c graphic file with name nihms517620t29.jpg Ph graphic file with name nihms517620t30.jpg 33
24d graphic file with name nihms517620t31.jpg Ph Ph 39
24e graphic file with name nihms517620t32.jpg Ph Ph 22