Table I.
Univariate analysis for the 5-year disease-specific survival in patients with stage II colorectal cancer.
| Factors | No. of patients | 5-year survival rate (%) | P-value |
|---|---|---|---|
| Age (years) | |||
| 0–70 | 73 | 79 | NS |
| ≥71 | 36 | 81 | |
| Gender | |||
| Male | 61 | 85 | NS |
| Female | 48 | 88 | |
| Location of tumor | |||
| Right colon | 21 | 95 | NS |
| Left colon | 52 | 82 | |
| Rectum | 36 | 68 | |
| No. of resected lymph nodes | |||
| 0–11 | 43 | 81 | NS |
| ≥12 | 66 | 79 | |
| Bowel obstruction | |||
| Absent | 99 | 83 | <0.01 |
| Present | 10 | 50 | |
| Tumor size (cm) | |||
| 0–4 | 29 | 90 | NS |
| >4 | 80 | 76 | |
| Depth of tumor invasion | |||
| T3 | 80 | 90 | NS |
| T4 | 29 | 76 | |
| Differentiation | |||
| High | 68 | 84 | NS |
| Moderate | 36 | 75 | |
| Poor/mucinous | 5 | 60 | |
| Lymphatic invasion | |||
| Absent, mild | 98 | 90 | <0.01 |
| Moderate, severe | 11 | 55 | |
| Venous invasion | |||
| Absent | 80 | 89 | NS |
| Present | 29 | 79 | |
| Tumor budding | |||
| Absent | 70 | 84 | NS |
| Present | 39 | 90 | |
| Peritumoral lymphocytes | |||
| Inconspicuous | 40 | 83 | NS |
| Conspicuous | 69 | 88 | |
| Tumor growth pattern | |||
| Expansive | 30 | 91 | NS |
| Infiltrative | 79 | 84 | |
| p53 | |||
| Negative | 49 | 84 | NS |
| Positive | 60 | 88 | |
| CD10 | |||
| Negative | 70 | 83 | NS |
| Positive | 39 | 92 | |
| Angiogenesis (microvessel count) | |||
| 0–50 | 90 | 80 | NS |
| >50 | 19 | 79 | |
| Ki-67 index | |||
| Sparse | 94 | 78 | NS |
| Diffuse | 15 | 93 | |
| Lymph node micrometastasis | |||
| 0–3 positive nodes | 96 | 92 | <0.01 |
| ≥4 positive nodes | 13 | 46 |
NS, non-significant.