Table 2. Orphan drugs approved for LSDs in the US between 1983 and 2010.
| Commercial name/year of approval | International non-proprietary name | Indication |
|---|---|---|
| Ceredase 1991 |
Aglucerase |
Gaucher disease |
| Cerezyme 1994 |
Imiglucerase |
Gaucher disease |
| Fabrazyme 2003 |
Agalsidase β |
Fabry disease |
| Aldurazyme 2003 |
Laronidase |
Mucopolysaccharidosis-I |
| Zavesca 2003 |
Miglustat |
Gaucher disease |
| Naglazyme 2005 |
Galsulfase |
Muccopolysacchridosis-VI |
| Myozyme 2006 |
Alglucosidase alfa |
Pompe Disease |
| Elaprase 2006 |
Idursulfase |
Mucopolysaccharidosis-II |
| Vpriv 2010 | Velaglucirase alfa | Gaucher disease |