Table 3.
The median methylation values for 7 CHD candidate genes showing significant differences between TOF cases and controls
| Gene | Gene bank accession | Gene amplicon | Control, median (IQR); N | TOF, median (IQR); N | P value | Position |
|---|---|---|---|---|---|---|
|
EGFR |
NM_201282 |
EGFR _M1 |
52.75(44.00-56.35);N = 6 |
60.50(56.10-68.08);N = 33 |
0.0042** |
CpGI |
|
EVC2 |
NM_001166136 |
EVC2 _M1 |
29.63(18.84-32.25);N = 6 |
43.88(36.44-53.28);N = 32 |
0.0005*** |
CpGI |
|
NFATC2 |
NM_001136021 |
NFATC2_M2 |
21.80(17.50-25.53);N = 6 |
30.29(26.06-36.57);N = 41 |
0.0067** |
CpGI |
|
NR2F2 |
NM_021005 |
NR2F2 |
62.50(54.35-68.30);N = 6 |
43.40(33.90-53.10);N = 41 |
0.0161* |
CpGI shore |
|
TBX5 |
NM_080717 |
TBX5_M1 |
42.04(32.97-54.69);N = 6 |
57.13(50.69-67.31);N = 37 |
0.0207* |
CpGI shore |
|
CFC1B |
NM_001079530 |
CFC1B_M2 |
48.16(40.36-59.25);N = 6 |
63.50(53.57-80.60);N = 39 |
0.0178* |
TSS |
| GJA5 | NM_005266 | GJA5 | 32.83(29.00-36.08);N = 6 | 44.00(34.67-53.92);N = 36 | 0.0138* | TSS |
*P < 0.05, **P < 0.01, ***P < 0.001 (Mann–Whitney test), IQR, Interquartile range.