Table 4.
Median mRNA levels for 7 candidate genes in TOF cases and controls
| Gene | Gene bank accession | Control, median (IQR), N | TOF, median (IQR), N | mRNA fold change | P value |
|---|---|---|---|---|---|
|
EGFR |
NM_201282 |
3.98 (1.84 – 6.93); N = 6 |
0.61 (0.46 – 0.75); N = 33 |
0.15 |
0.0003*** |
|
EVC2 |
NM_001166136 |
3.95 (1.50 – 6.21); N = 6 |
0.96 (0.79 – 1.56); N = 32 |
0.24 |
0.0033** |
|
NFATC2 |
NM_001136021 |
7.72 (4.60 – 11.50); N = 6 |
1.39 (0.97 – 1.88); N = 41 |
0.18 |
0.0043** |
|
NR2F2 |
NM_021005 |
3.27 (1.34 – 4.88); N = 6 |
1.12 (0.70 – 1.30); N = 41 |
0.34 |
0.0039** |
|
TBX5 |
NM_080717 |
1.49 (1.35 – 4.42);N = 6 |
0.41 (0.19 – 0.67); N = 37 |
0.28 |
0.0013** |
|
CFC1B |
NM_001079530 |
2.20 (1.57 – 7.50); N = 6 |
0.66 (0.31 – 1.07); N = 39 |
0.30 |
0.0016** |
| GJA5 | NM_005266 | 0.77 (0.34 – 1.06); N = 6 | 0.19 (0.16 – 0.32); N = 36 | 0.25 | 0.0053** |
**P < 0.01, ***P < 0.001 (Mann–Whitney test), IQR, Interquartile range.